Endocrine Abstracts

CIDEC is a lipid droplet-targeting protein that promotes triglyceride accumulation and inhibits lipolysis. CIDEC is regulated by peroxisome proliferator-activated receptor γ (PPARγ). Previous studies demonstrate that CIDEC down-regulation is involved in TNFα-induced lipolysis. Here, we focus on the signalling pathway to clarify the mechanism of TNFα-mediated CIDEC down-regulation. CIDEC is significantly decreased in subcutaneous adipose tissue in obese subj...